The Battle of Nineveh is conventionally dated between 613 and 611 BC, with 612 BC being the most supported date. Rebelling against the Assyrians, an allied army which combined the forces of Medes and the Babylonians besieged Nineveh and sacked 750 hectares of what was, at that time, one of the greatest cities in the world. The fall of Nineveh led to the destruction of the Neo-Assyrian Empire over the next three years as the dominant state in the Ancient Near East. Archeological records show that the capital of the once mighty Assyrian Empire was extensively de-urbanized and depopulated in the decades and centuries following the battle. A garbled account of the fall of the city later led to the story of the legendary king Sardanapalus.

The Neo-Assyrian Empire was the fourth and penultimate stage of ancient Assyrian history. Beginning with the accession of Adad-nirari II in 911 BC, the Neo-Assyrian Empire grew to dominate the ancient Near East throughout much of the 8th and 7th centuries BC, becoming the largest empire in history up to that point. Because of its geopolitical dominance and ideology based in world domination, the Neo-Assyrian Empire is by many researchers regarded to have been the first world empire in history. It influenced other empires of the ancient world culturally, administratively, and militarily, including the Babylonians, the Achaemenids, and the Seleucids. At its height, the empire was the strongest military power in the world and ruled over all of Mesopotamia, the Levant and Egypt, as well as parts of Anatolia, Arabia and modern-day Iran and Armenia.