The Battle of Santiago de Cuba was a decisive naval engagement that occurred on July 3, 1898 between an American fleet, led by William T. Sampson and Winfield Scott Schley, against a Spanish fleet led by Pascual Cervera y Topete, which occurred during the Spanish–American War. The significantly more powerful US Navy squadron, consisting of four battleships and two armored cruisers, decisively defeated an outgunned squadron of the Royal Spanish Navy, consisting of four armored cruisers and two destroyers. All of the Spanish ships were sunk for no American loss. The crushing defeat sealed the American victory in the Cuban theater of the war, ensuring the independence of Cuba from Spanish rule.

The Spanish–American War began in the aftermath of the internal explosion of USS Maine in Havana Harbor in Cuba, leading to United States intervention in the Cuban War of Independence. The war led to the United States emerging predominant in the Caribbean region, and resulted in U.S. acquisition of Puerto Rico, Guam, and the Philippines. It also led to United States involvement in the Philippine Revolution and later to the Philippine–American War.