William Thomas Sampson was a United States Navy rear admiral known for his victory in the Battle of Santiago de Cuba during the Spanish–American War.

The Battle of Santiago de Cuba was a decisive naval engagement that occurred on July 3, 1898 between an American fleet, led by William T. Sampson and Winfield Scott Schley, against a Spanish fleet led by Pascual Cervera y Topete, which occurred during the Spanish–American War. The significantly more powerful US Navy squadron, consisting of four battleships and two armored cruisers, decisively defeated an outgunned squadron of the Royal Spanish Navy, consisting of four armored cruisers and two destroyers. All of the Spanish ships were sunk for no American loss. The crushing defeat sealed the American victory in the Cuban theater of the war, ensuring the independence of Cuba from Spanish rule.