The Battle of Stones River, also known as the Second Battle of Murfreesboro, was fought from December 31, 1862, to January 2, 1863, in Middle Tennessee, as the culmination of the Stones River Campaign in the Western Theater of the American Civil War. Of the major battles of the war, Stones River had the highest percentage of casualties on both sides. The battle ended in Union victory after the Confederate army's withdrawal on January 3, largely due to a series of tactical miscalculations by Confederate Gen. Braxton Bragg, but the victory was costly for the Union army. Nevertheless, it was an important victory for the Union because it provided a much-needed boost in morale after the Union's recent defeat at Fredericksburg and also reinforced President Abraham Lincoln's foundation for issuing the Emancipation Proclamation, which ultimately discouraged European powers from intervening on the Confederacy's behalf.

Middle Tennessee is one of the three Grand Divisions of Tennessee that composes roughly the central portion of the state. It is delineated according to state law as 41 of the state's 95 counties. Middle Tennessee contains the state's capital and largest city, Nashville, as well as Clarksville, the state's fifth largest city, and Murfreesboro, the state's sixth largest city and largest suburb of Nashville. The Nashville metropolitan area, located entirely within the region, is the most populous metropolitan area in the state, and the Clarksville metropolitan area is the state's sixth most populous. Middle Tennessee is both the largest, in terms of land area, and the most populous of the state's three Grand Divisions.