Isabelle Case La Follette was a women's suffrage, peace, and civil rights activist in Wisconsin, United States. She worked with the Woman's Peace Party during World War I. At the time of her death in 1931, The New York Times called her "probably the least known yet most influential of all American women who have had to do with public affairs in this country." She was the wife and helpmate of Robert "Fighting Bob" La Follette—a prominent Progressive Republican politician both in Wisconsin and on the national scene—and as co-editor with her husband of La Follette's Weekly Magazine.

Robert Marion La Follette Sr., was an American lawyer and politician. He represented Wisconsin in both chambers of Congress and served as the governor of Wisconsin from 1901 to 1906. A Republican for most of his life, he ran for president of the United States as the nominee of his own Progressive Party in the 1924 presidential election. Historian John D. Buenker describes La Follette as "the most celebrated figure in Wisconsin history".