Berbice is a region along the Berbice River in Guyana, which was between 1627 and 1792 a colony of the Dutch West India Company and between 1792 and 1815 a colony of the Dutch state. After having been ceded to the United Kingdom of Great Britain and Ireland in the latter year, it was merged with Demerara-Essequibo to form the colony of British Guiana in 1831. It became a county of British Guiana in 1838 till 1958. In 1966, British Guiana gained independence as Guyana and in 1970 it became a republic as the Co-operative Republic of Guyana.

The Berbice Rebellion was a slave rebellion in Guyana that began on 23 February 1763 and lasted to December, with leaders including Coffij. The first major slave revolt in South America, it is seen as a major event in Guyana's anti-colonial struggles, and when Guyana became a republic in 1970 the state declared 23 February as a day to commemorate the start of the Berbice slave revolt.