Berbice is a region along the Berbice River in Guyana, which was between 1627 and 1792 a colony of the Dutch West India Company and between 1792 and 1815 a colony of the Dutch state. After having been ceded to the United Kingdom of Great Britain and Ireland in the latter year, it was merged with Demerara-Essequibo to form the colony of British Guiana in 1831. It became a county of British Guiana in 1838 till 1958. In 1966, British Guiana gained independence as Guyana and in 1970 it became a republic as the Co-operative Republic of Guyana.

The Berbice River, located in eastern Guyana, is one of the country's major rivers. It rises in the highlands of the Rupununi region and flows northward for 595 kilometres (370 mi) through dense forests to the coastal plain. The river's tidal limit is between 160 and 320 km (99–199 mi) from the sea.