The Berbice Rebellion was a slave rebellion in Guyana that began on 23 February 1763 and lasted to December, with leaders including Coffij. The first major slave revolt in South America, it is seen as a major event in Guyana's anti-colonial struggles, and when Guyana became a republic in 1970 the state declared 23 February as a day to commemorate the start of the Berbice slave revolt.

A slave rebellion is an armed uprising by slaves, as a way of fighting for their freedom. Rebellions of slaves have occurred in nearly all societies that practice slavery or have practiced slavery in the past. A desire for freedom and the dream of successful rebellion is often the greatest object of song, art, and culture amongst the enslaved population. These events, however, are often violently opposed and suppressed by slaveholders.