Berlin Friedrichstraße is a railway station in the German capital Berlin. It is located on the Friedrichstraße, a major north-south street in the Mitte district of Berlin, adjacent to the point where the street crosses the river Spree. Underneath the station is the U-Bahn station Friedrichstraße.

The Friedrichstraße is a major culture and shopping street in central Berlin, forming the core of the Friedrichstadt neighborhood and giving the name to Berlin Friedrichstraße station. It runs from the northern part of the old Mitte district to the Hallesches Tor in the district of Kreuzberg.