The Biddle family of Philadelphia, Pennsylvania is an Old Philadelphian family descended from English immigrants William Biddle (1630–1712) and Sarah Kempe (1634–1709), who arrived in the Province of New Jersey in 1681. Quakers, they had emigrated from England in part to escape religious persecution. Having acquired extensive rights to more than 43,000 acres (170 km2) of lands in West Jersey, they settled first at Burlington, a city which developed along the east side of the Delaware River.

Nicholas Biddle was an American financier who served as the third and last president of the Second Bank of the United States. Throughout his life Biddle worked as an editor, diplomat, author, and politician who served in both houses of the Pennsylvania state legislature. He is best known as the chief opponent of Andrew Jackson in the Bank War.