The Big Maria Mountains are located in the southeastern part of the U.S. state of California, near the Colorado River and Arizona. The range lies between Blythe and Vidal, and west of U.S. Route 95 in California and east of Midland. The mountains are home to the Eagle Nest Mine and reach an elevation of 1,030 m (3,380 ft). A power line that runs from Parker Dam to Yuma, Arizona runs through the range. A smaller range, the Little Maria Mountains, lie to the west of the Big Marias.

U.S. Route 95 (US 95) is a United States Numbered Highway, stretching from the Mexican border in San Luis, Arizona to the Canadian border near Eastport, Idaho. The California portion of US 95 traverses through the far eastern edges of both Riverside and San Bernardino counties. US 95 serves Blythe and Needles and junctions with SR 62 at Vidal Junction.