U.S. Route 95 (US 95) is a United States Numbered Highway, stretching from the Mexican border in San Luis, Arizona to the Canadian border near Eastport, Idaho. The California portion of US 95 traverses through the far eastern edges of both Riverside and San Bernardino counties. US 95 serves Blythe and Needles and junctions with SR 62 at Vidal Junction.

U.S. Route 95 is a major U.S. highway traversing the U.S. state of Nevada from north to south directly through Las Vegas and providing connections to both Carson City and Reno. US 95 is cosigned with Interstate 80 for 95 miles (153 km) between a junction in Trinity and Winnemucca before heading north into Oregon at McDermitt. At 646.71 miles (1,040.78 km), it is the longest highway in Nevada.