Binondo is a district in Manila and is referred to as the city's Chinatown. Its influence extends beyond to the places of Quiapo, Santa Cruz, San Nicolas and Tondo. It is the oldest Chinatown in the world, established in 1594 by the Spaniards as a settlement near Intramuros but across the Pasig River for Catholic Chinese; it was positioned so that the colonial administration could keep a close eye on their migrant subjects. It was already a hub of Chinese commerce even before the Spanish colonial period. Binondo is the center of commerce and trade of Manila, where all types of business run by Filipino-Chinese thrive.

Manila, officially the City of Manila, is the capital and second-most-populous city of the Philippines. Located on the eastern shore of Manila Bay on the island of Luzon, it is classified as a highly urbanized city. As of 2019, it is the world's most densely populated city proper. It was the first chartered city in the country, and was designated as such by the Philippine Commission Act No. 183 on July 31, 1901. It became autonomous with the passage of Republic Act No. 409, "The Revised Charter of the City of Manila", on June 18, 1949. Manila is considered to be part of the world's original set of global cities because its commercial networks were the first to extend across the Pacific Ocean and connect Asia with the Spanish Americas through the galleon trade; when this was accomplished, it was the first time an uninterrupted chain of trade routes circling the planet had been established.