Birmingham is a city in the north central region of Alabama. Birmingham is the county seat of Jefferson County, Alabama's most populous county. As of the 2022 census estimates, Birmingham had a population of 196,910, down 2% from the 2020 census, making it Alabama's third-most populous city after Huntsville and Montgomery. The broader Birmingham metropolitan area had a 2020 population of 1,115,289, and is the largest metropolitan area in Alabama as well as the 50th-most populous in the United States. Birmingham serves as an important regional hub and is associated with the Deep South, Piedmont, and Appalachian regions of the nation.

Jefferson County is the most populous county in the U.S. state of Alabama, located in the central portion of the state. As of the 2020 census, its population was 674,721. Its county seat is Birmingham. Its rapid growth as an industrial city in the 20th century, based on heavy manufacturing in steel and iron, established its dominance. Jefferson County is the central county of the Birmingham-Hoover, AL Metropolitan Statistical Area.