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Bodega Bay

Bodega Bay is a shallow, rocky inlet of the Pacific Ocean on the coast of northern California in the United States. It is 5 mi across and is located 40 mi northwest of San Francisco and 20 mi west of Santa Rosa; the bay straddles the boundary between Sonoma County to Marin County to the south. The bay is a marine habitat used for navigation and commercial and sport fishing including shellfish harvesting. Bodega Bay is protected on its north end from the Pacific Ocean by Bodega Head, which shelters the small Bodega Harbor and is separated from the main bay by a jetty; the San Andreas Fault runs parallel to the coastline and bisects Bodega Head, which lies on the Pacific Plate. The village of Bodega Bay sits on the east side of Bodega Harbor; the bay connects on its south end to the mouth of Tomales Bay. Streams flowing into Bodega Bay include the Americano Creek. Accessible beaches on Bodega Bay include Pinnacle Gulch. Apart from the harbor, all of Bodega Bay lies within the boundaries of the Gulf of the Farallones National Marine Sanctuary.

Coast Miwok Native Americans lived on the shores of Bodega Bay. Documented village names include: Helapattai, Hime-takala, Ho-takala, Tokau. There is speculation that Bodega Bay may have been Sir Francis Drake's Nova Albion landing location on the California coast. Present day Bodega Bay was first charted in 1775 by the Spanish Peruvian explorer of the Spanish Navy Juan Francisco de la Bodega y Quadra, but the bay, named for him was not present day Bodega, but Tomales Bay, his ship, the Sonora, anchored in the lee of Tomales Point on October 3, 1775, departing the next day. Bodega y Quadra named Tomales Bay Puerto de la Bodega. "There is no evidence in the journal or on the charts that Bodega y Quadra saw the entrance to Bodega Harbor or knew of the lagoon to the north". Bodega y Quadra was not able to; as commandant of the naval base at San Blas, New Spain, Bodega y Quadra sent other expeditions to Bodega Bay with the intention of establishing a colony and mission there. It was decided, that the location was non-ideal.

The first Russians to see Bodega Bay were the supervisors of the Aleut hunting parties aboard the American otter hunting ship Peacock in 1807. Timofei Osipovich Tarakanov of the Russian-American Company returned to Novo Arkhangelsk and reported the location to Alexander Andreyevich Baranov, the chief administrator of the RAC. Baranov instructed his assistant Ivan Kuskov to survey the area for a settlement. Kuskov, the Commerce Counselor of the Russian-American Company sailing in the Kodiak, entered Bodega Bay on January 8, 1809. Instructed by Baranov to leave "secret signs", Kuskov buried possession plaques at Trinidad Harbor, Bodega Head and on the north shore of San Francisco Bay, indicating the company's intention to claim this section of northern California for Russia. Temporary buildings were erected to house the ship's complement of 190 crew The Kodiak remained in Bodega Bay until October 1809, returning to Alaska with more than 2,000 otter pelts. Kuskov returned to Novo Arkhangelsk, reporting abundant fur bearing mammals, fish and tillable lands.

Baranov instructed Kuskov to establish a permanent settlement in the area. In 1811 Kuskov returned, this time aboard the Chirikov but found fewer otter in Bodega Bay. Three American ships were operating in the area from a base in Drake's Bay, sending hunters into San Francisco Bay and the surrounding bays. Kuskov sailed the Brig Chirikov back to present day Bodega Harbor on March 15, 1812. Zaliv Rumyantsev appears on the earliest Russian charts of Bodega Bay identifying present day Bodega Bay and Bodega Harbor. Bodega Head was named Mouis Rumyantsev. Tomales Point was named Point Great Bodega and Tomales Bay Great Bodega Bay, more or less conforming to Bodega y Quadra's original naming. On his return Kuskov found otter now scarce in Bodega Bay, the harbor having been frequented by numerous American and English otter-hunting expeditions. After exploring the area they ended up selecting a place 15 mi north that the native Kashaya Pomo people called Mad shui nui or Metini. Metini, the seasonal home of the native Kashaya Pomo people, had a modest anchorage and abundant natural resources and would become the Russian settlement of Fort Ross.

By 1817 sea otter in the area were eliminated by international over-hunting. Zaliv Rumyantsev continued to be the main entrepôt for the Russian Colony until January 1842, the earliest European structures built at Bodega Bay were the wharf and barracks of the Russian-American Company. Bodega Bay remained an active harbor for shipping lumber until the 1870s, when the North Pacific Coast Railroad was built, bypassing the coast in favor of a more inland route. A plan by Pacific Gas & Electric to build a nuclear power plant received significant negative attention from local citizens, beginning in 1958. By 1964, the plans for the plant were abandoned. Bodega Bay was the setting for the 1963 Alfred Hitchcock film The Birds starring Rod Taylor, Tippi Hedren and Suzanne Pleshette. In October 2017, Bodega Bay, on the northwest edge of Sonoma County, served as a site of refuge and supply depot for evacuees from an historic fast-moving destructive fire in northern California. People

King Arthur: Legend of the Sword

King Arthur: Legend of the Sword is a 2017 epic fantasy action adventure film directed by Guy Ritchie who co-wrote the film with Joby Harold and Lionel Wigram from a story by Harold and David Dobkin, inspired by Arthurian legends. The film stars Charlie Hunnam as the title character and Jude Law as the tyrannical king Vortigern, attempting to kill him, with Àstrid Bergès-Frisbey, Djimon Hounsou, Aidan Gillen, Eric Bana in supporting roles. King Arthur premiered at the TCL Chinese Theater on 8 May 2017 and was theatrically released in 2D and RealD 3D on 12 May 2017 in the United States and 19 May 2017 in the United Kingdom; the film grossed $148 million worldwide against its $175 million production budget, with critics "warning audiences to stay away". The film was meant to be the first in a six-film franchise, but the planned sequels were cancelled after it underperformed at the box office and lost Warner Bros. and Village Roadshow Pictures over $150 million. Mordred, an iron-fisted warlock, his armies lay siege to Camelot, seeking to establish the dominance of mages over humankind.

Uther Pendragon, king of the Britons, beheads him, saving Camelot. Uther's treacherous younger brother Vortigern, who covets the throne, orchestrates a coup and sacrifices his wife Elsa to moat hags to become a demon knight, who kills Uther's wife Igraine and slays Uther in combat; the only survivor is Uther's son Arthur, who drifts away in a boat and ends up in Londinium, where he is found and raised by prostitutes. Arthur grows into a skilled man of the streets. Arthur and his friends confront a group of Vikings who had mistreated one of the prostitutes, forcing them to pay her restitution. Afterwards, the brothel is raided by the Blacklegs, Vortigern's minions, Arthur learns that the Vikings were under the king's protection. Arthur is caught and put on a ship with hundreds of other men. Arthur is able to remove the sword but is overwhelmed by its power and passes out. Vortigern meets with him in the dungeon. Meanwhile, a mage identifying herself as an acolyte of Merlin presents herself to Uther's former general, Sir Bedivere.

At Arthur's planned execution, the mage uses her magic to stage a diversion while Bedivere's men rescue Arthur. Taken to Bedivere's hideout, Arthur refuses to help them; the mage persuades Bedivere to take Arthur to a realm called the "Darklands," where he's given a vision of how Uther sacrificed himself to save Arthur and entomb the sword in stone. Arthur learns Vortigern was responsible for persuading Mordred to rebel against humanity, he returns determined to destroy Vortigern. With his friends and Bedivere's men, Arthur stages a series of ambushes against Vortigern, culminating in an assassination attempt in Londinium; the rebels sense a trap but attack anyway, fleeing to a fighters' school run by Arthur's mentor George, where they are overrun by the Blacklegs. Seeing the mage held at knifepoint, Arthur unleashes Excalibur's potential, single-handedly killing all of the soldiers and allowing most of the rebels to escape the city. However, in the ensuing chaos, Arthur's close friend Back Lack is wounded and murdered by Vortigern in front of Arthur and Back Lack's son that night.

Ashamed of his failures, Arthur tries to throw away the sword, but the Lady of the Lake returns it and shows him a vision of England's future under Vortigern's rule. Coming to terms with his responsibility, Arthur reunites with Bedivere; when they return to the rebel hideout, they discover all of their allies dead, Vortigern having found them and delivered an ultimatum: if Arthur does not surrender himself, the captured mage will die. Arthur surrenders himself, but as Vortigern is about to execute his nephew, a giant snake summoned by the mage attacks and devours Vortigern's men. While Bedivere and the others lead an attack on the castle, a desperate Vortigern sacrifices his only daughter and is transformed into the demon knight, confronting Arthur in a separate dimension. Despite his fighting skill, Arthur is beaten, he is about to submit when he witnesses a vision of his father, convincing him to accept the sword and his character as his own. Arthur violently blesses him as he dies. In the aftermath, Arthur dissolves Vortigern's pact with the Vikings and begins building a Round Table where his knighted friends will meet.

Blue and the prostitutes arrive with the crown of Uther, which Arthur accepts, holding the sword aloft. Charlie Hunnam as King Arthur, Uther's son, Vortigern's nephew and the would-be king of Britain, raised by prostitutes. Àstrid Bergès-Frisbey as the Mage, a woman working for Merlin who supports Arthur and the resistance. Djimon Hounsou as Sir Bedivere, the leader of the resistance and a former knight of Uther. Aidan Gillen as Goosefat Bill Wilson, a skilled archer, Bedivere's friend, former knight of Uther and member of the resistance. Mikael Persbrandt as Greybeard, a Viking who has deals with Vortigern. Jude Law as Vortigern, Uther's brother, Elsa's husband, Catia's father, Arthur's uncle and the tyrannical ruthless king of Britain, he is able to transform himself into a demonic knight. Eric Bana as Uther Pendragon, Vortigern's brother, Arthur's father and the king of Britain. Annabelle Wallis as Maggie, a member of Vortigern's Court who helps the resistance. Kingsley Ben-Adir as Sir Tristan "Wet Stick", Arthur and Back Lack's childhood friend, knighted by Bedivere.

Neil Maskell as Back Lack and Tristan's childhood friend and Blue's father, who helps the resistance. Tom Wu as George, Arthur's Chinese friend and teacher who owns a ma

CSNK2B

Casein kinase II subunit beta is a protein that in humans is encoded by the CSNK2B gene. This gene encodes the beta subunit of casein kinase II, a ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription and replication; the enzyme localizes to the Golgi apparatus. Casein kinase, a ubiquitous, well-conserved protein kinase involved in cell metabolism and differentiation, is characterised by its preference for Serine or Threonine in acidic stretches of amino acids; the enzyme is a tetramer of 2 alpha- and 2 beta-subunits. However, some species possess 2 related forms of the alpha-subunit, while others possess 2 related beta-subunits; the alpha-subunit is the catalytic unit and contains regions characteristic of serine/threonine protein kinases. The beta-subunit is believed to be regulatory, possessing an N-terminal auto-phosphorylation site, an internal acidic domain, a potential metal-binding motif; the beta subunit is a conserved protein of about 25kDa that contains, in its central section, a cysteine-rich motif, CXC, that could be involved in binding a metal such as zinc.

The mammalian beta-subunit gene promoter shares common features with those of other mammalian protein kinases and is related to the promoter of the regulatory subunit of cAMP-dependent protein kinase. CSNK2B has been shown to interact with CD163, CSNK2A2, Casein kinase 2, alpha 1, FGF1, TRIB3, CDC34, Ribosomal protein L5, BTF3, BRCA1, RNF7, P70-S6 Kinase 1 and APC. Human CSNK2B genome location and CSNK2B gene details page in the UCSC Genome Browser. PDBe-KB provides an overview of all the structure information available in the PDB for Human Casein kinase II subunit beta