Bonnie Bassler

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Bonnie Bassler
Born
Bonnie Lynn Bassler

1962 (age 56–57)
NationalityAmerican
CitizenshipU.S. Citizen
Alma materUniversity of California, Davis
Johns Hopkins University
Known forQuorum sensing
Spouse(s)Todd Reichart
AwardsWiley Prize in Biomedical Science (2009)
Richard Lounsbery Award (2011)
Shaw Prize (2015)
Pearl Meister Greengard Prize (2016)
Foreign Member of the Royal Society[1]
Scientific career
InstitutionsPrinceton University

Bonnie Lynn Bassler (born 1962)[2] is an American molecular biologist who has researched chemical communication between bacteria known as quorum sensing, and contributed to the idea that disruption of chemical signaling can be used as an antimicrobial therapy. She is the Squibb Professor in Molecular Biology and chair of the Department of Molecular Biology at Princeton University, she is a Howard Hughes Medical Institute Investigator and her research focuses on cell-to-cell communication in bacteria.[3]

She has received numerous awards for her research, including the Wiley Prize in Biomedical Sciences (2009), the Richard Lounsbery Award (2011), and the L’Oreal-UNESCO award (2012), a MacArthur Fellowship[4] (2002),[5] and the Pearl Meister Greengard Prize (2016)[6], she is a former president of the American Society for Microbiology, a member of the National Academy of Sciences, and a former six-year member of National Science Board.

Early life and education[edit]

Born in Chicago and raised in Danville, California,[7] Bassler began her career in science "as a veterinarian’s assistant at the Miami Zoo and later at a local dog and cat clinic."[8] Bassler received a Bachelor of Science in biochemistry from the University of California, Davis and a Ph.D. in biochemistry from Johns Hopkins University.[9] She made key insights into the mechanism by which bacteria communicate,[10] known as quorum sensing, her postdoctoral research was conducted at Agouron Institute in genetics for four years[11] before joining the Princeton faculty in 1994. She is currently the chair of the department of molecular biology and the Squibb Professor in molecular biology.[12]

Honors and awards[edit]

Notable publications[edit]

  • Ng, W. L., & Bassler, B. L. (2009). Bacterial quorum-sensing network architectures. Annual review of genetics, 43, 197-222.[34]
  • Bassler, B. L., & Losick, R. (2006). Bacterially speaking. Cell, 125(2), 237-246.[35]
  • Camilli, A., & Bassler, B. L. (2006). Bacterial small-molecule signaling pathways. Science, 311(5764), 1113-1116.[36]
  • Waters, C. M., & Bassler, B. L. (2005). Quorum sensing: cell-to-cell communication in bacteria. Annu. Rev. Cell Dev. Biol., 21, 319-346.[37]
  • Lenz, D. H., Mok, K. C., Lilley, B. N., Kulkarni, R. V., Wingreen, N. S., & Bassler, B. L. (2004). The small RNA chaperone Hfq and multiple small RNAs control quorum sensing in Vibrio harveyi and Vibrio cholerae. Cell, 118(1), 69-82.[38]
  • Chen, X., Schauder, S., Potier, N., Van Dorsselaer, A., Pelczer, I., Bassler, B. L., & Hughson, F. M. (2002). Structural identification of a bacterial quorum-sensing signal containing boron. Nature, 415(6871), 545.[39]
  • Miller, M. B., & Bassler, B. L. (2001). Quorum sensing in bacteria. Annual Reviews in Microbiology, 55(1), 165-199.[40]
  • Schauder, S., Shokat, K., Surette, M. G., & Bassler, B. L. (2001). The LuxS family of bacterial autoinducers: biosynthesis of a novel quorum‐sensing signal molecule. Molecular microbiology, 41(2), 463-476.[41]
  • Surette, M. G., Miller, M. B., & Bassler, B. L. (1999). Quorum sensing in Escherichia coli, Salmonella typhimurium, and Vibrio harveyi: a new family of genes responsible for autoinducer production. Proceedings of the National Academy of Sciences, 96(4), 1639-1644.[42]
  • Bassler, B. L. (1999). How bacteria talk to each other: regulation of gene expression by quorum sensing. Current opinion in microbiology, 2(6), 582-587.[43]
  • Bassler, B. L., Wright, M., Showalter, R. E., & Silverman, M. R. (1993). Intercellular signalling in Vibrio harveyi: sequence and function of genes regulating expression of luminescence. Molecular microbiology, 9(4), 773-786.[44]

References[edit]

  1. ^ Staff. "Professor Bonnie L. Bassler ForMemRS". The Royal Society. Retrieved 2012-10-21.
  2. ^ a b "Book of Members, 1780-2010: Chapter B" (PDF). American Academy of Arts and Sciences. Retrieved May 20, 2011.
  3. ^ "Bonnie Bassler at Princeton".
  4. ^ "MacArthur Foundation". www.macfound.org.
  5. ^ "Princeton university news".
  6. ^ "Princeton news".
  7. ^ a b Ahmed, F. (2008). "Profile of Bonnie L. Bassler". Proceedings of the National Academy of Sciences. 105 (13): 4969–4971. doi:10.1073/pnas.0705870105. PMC 2278219. PMID 18362352.
  8. ^ "The Shaw Prize - Top prizes for astronomy, life science and mathematics". www.shawprize.org. Retrieved 2019-03-16.
  9. ^ "Bonnie L. Bassler, Ph.D." Howard Hughes Medical Institute. Retrieved May 20, 2011.
  10. ^ Schauder, S.; Bassler, B. L. (2001). "The languages of bacteria". Genes & Development. 15 (12): 1468–80. doi:10.1101/gad.899601. PMID 11410527.
  11. ^ Ahmed, Farooq (2008-04-01). "Profile of Bonnie L. Bassler". Proceedings of the National Academy of Sciences. 105 (13): 4969–4971. doi:10.1073/pnas.0705870105. ISSN 0027-8424. PMID 18362352.
  12. ^ "Bonnie Bassler". Broad Institute. 20 March 2018. Retrieved 3 May 2019.
  13. ^ "MacArthur Foundation". www.macfound.org.
  14. ^ "Elected Fellows". AAAS - The World's Largest General Scientific Society. 2016-10-21. Retrieved 2017-03-10.
  15. ^ "Special Recognitions 2008". World Cultural Council. Archived from the original on November 5, 2013. Retrieved August 19, 2013.
  16. ^ "Eighth Annual Wiley Prize in Biomedical Sciences Awarded to Dr. Bonnie Bassler of Princeton University".
  17. ^ "Wiley Foundation Past winners".
  18. ^ "The Nifty Fifty (times 2)". USA Science and Engineering Festival. 2010. Archived from the original on 2012-07-23. Retrieved 2012-10-20.
  19. ^ "National Science Board". National Science Board. Retrieved 2017-03-10.
  20. ^ http://www.nasonline.org, National Academy of Sciences -. "Richard Lounsbery Award". www.nasonline.org. Retrieved 2017-03-10.
  21. ^ L’Oréal Foundation (26 March 2012). "Bonnie Bassler, 2012 L'Oréal-UNESCO Awards Laureate for North America" – via YouTube.
  22. ^ "American Society for Microbiology". www.asm.org. Retrieved 2017-03-10.
  23. ^ "Members | American Philosophical Society". www.amphilsoc.org. Retrieved 2017-03-10.
  24. ^ "2014 EMD Millipore Alice C. Evans Award Laureate". www.asm.org. Retrieved 2018-10-20.
  25. ^ "Two Princeton professors to receive Phi Beta Kappa teaching awards". Princeton University. Retrieved 2018-10-20.
  26. ^ "Shaw Laureates in 2015 in Life Science and Medicine: Announcement and Citation". Shaw Prize Foundation. Retrieved 2 June 2015.
  27. ^ "Recipients and Award Lectures". faseb.org. Retrieved 2017-03-10.
  28. ^ Alex; MacWade, ra; Editor, Assistant. "Molecular biologist Bonnie Bassler receives Rockefeller's Pearl Meister Greengard Prize | The Rockefeller University Benchmarks". Archived from the original on 2017-03-12. Retrieved 2017-03-10.
  29. ^ "The Pearl Meister Greengard Prize - The Rockefeller University". greengardprize.rockefeller.edu. Retrieved 2017-03-10.
  30. ^ "AAAS Fellow Bonnie Bassler wins 2016 Max Planck Research Award". American Association for the Advancement of Science. Retrieved 2018-10-20.
  31. ^ "National Academy of Medicine Elects 80 New Members - National Academy of Medicine". National Academy of Medicine. 2016-10-17. Retrieved 2018-10-20.
  32. ^ Webteam, University of Pittsburgh University Marketing Communications. "Bonnie Bassler, PhD". www.dicksonprize.pitt.edu. Retrieved 2018-10-20.
  33. ^ "Ernst Schering Prize 2018 – Schering Stiftung". scheringstiftung.de. Retrieved 2018-10-20.
  34. ^ Ng, Wai-Leung; Bassler, Bonnie L. (December 2009). "Bacterial Quorum-Sensing Network Architectures". Annual Review of Genetics. 43 (1): 197–222. doi:10.1146/annurev-genet-102108-134304. ISSN 0066-4197. PMC 4313539. PMID 19686078.
  35. ^ Bassler, Bonnie L.; Losick, Richard (April 2006). "Bacterially Speaking". Cell. 125 (2): 237–246. doi:10.1016/j.cell.2006.04.001. ISSN 0092-8674. PMID 16630813.
  36. ^ Camilli, Andrew; Bassler, Bonnie L. (2006-02-24). "Bacterial Small-Molecule Signaling Pathways". Science. 311 (5764): 1113–1116. doi:10.1126/science.1121357. ISSN 0036-8075. PMC 2776824. PMID 16497924.
  37. ^ Waters, Christopher M.; Bassler, Bonnie L. (November 2005). "QUORUM SENSING: Cell-to-Cell Communication in Bacteria". Annual Review of Cell and Developmental Biology. 21 (1): 319–346. doi:10.1146/annurev.cellbio.21.012704.131001. ISSN 1081-0706. PMID 16212498.
  38. ^ Lenz, Derrick H.; Mok, Kenny C.; Lilley, Brendan N.; Kulkarni, Rahul V.; Wingreen, Ned S.; Bassler, Bonnie L. (2004-07-09). "The Small RNA Chaperone Hfq and Multiple Small RNAs Control Quorum Sensing in Vibrio harveyi and Vibrio cholerae". Cell. 118 (1): 69–82. doi:10.1016/j.cell.2004.06.009. ISSN 0092-8674. PMID 15242645.
  39. ^ Chen, Xin; Schauder, Stephan; Potier, Noelle; Van Dorsselaer, Alain; Pelczer, István; Bassler, Bonnie L.; Hughson, Frederick M. (January 2002). "Structural identification of a bacterial quorum-sensing signal containing boron". Nature. 415 (6871): 545–549. doi:10.1038/415545a. ISSN 0028-0836. PMID 11823863.
  40. ^ Miller, Melissa B.; Bassler, Bonnie L. (October 2001). "Quorum Sensing in Bacteria". Annual Review of Microbiology. 55 (1): 165–199. doi:10.1146/annurev.micro.55.1.165. ISSN 0066-4227. PMID 11544353.
  41. ^ Schauder, Stephan; Shokat, Kevan; Surette, Michael G.; Bassler, Bonnie L. (2001-12-21). "The LuxS family of bacterial autoinducers: biosynthesis of a novel quorum-sensing signal molecule". Molecular Microbiology. 41 (2): 463–476. doi:10.1046/j.1365-2958.2001.02532.x. ISSN 0950-382X.
  42. ^ Surette, Michael G.; Miller, Melissa B.; Bassler, Bonnie L. (1999-02-16). "Quorum sensing in Escherichia coli, Salmonella typhimurium, and Vibrio harveyi: A new family of genes responsible for autoinducer production". Proceedings of the National Academy of Sciences. 96 (4): 1639–1644. doi:10.1073/pnas.96.4.1639. ISSN 0027-8424. PMC 15544. PMID 9990077.
  43. ^ Bassler, Bonnie L (December 1999). "How bacteria talk to each other: regulation of gene expression by quorum sensing". Current Opinion in Microbiology. 2 (6): 582–587. doi:10.1016/s1369-5274(99)00025-9. ISSN 1369-5274.
  44. ^ Bassler, Bonnie L.; Wright, Miriam; Showalter, Richard E.; Silverman, Michael R. (August 1993). "Intercellular signalling in Vibrio harveyi: sequence and function of genes regulating expression of luminescence". Molecular Microbiology. 9 (4): 773–786. doi:10.1111/j.1365-2958.1993.tb01737.x. ISSN 0950-382X.

External links[edit]