Brooke Army Medical Center (BAMC) is the United States Army's premier medical institution. Located on Fort Sam Houston, BAMC, a 425-bed Academic Medical Center, is the Department of Defense's largest facility and only Level 1 Trauma Center. BAMC is also home to the Center for the Intrepid, an outpatient rehabilitation facility. The center is composed of ten separate organizations, including community medical clinics, centered around the Army's largest in-patient hospital. BAMC is staffed by more than 8,000 Soldiers, Airmen, Sailors, Civilians, and Contractors providing care to wounded Service Members and the San Antonio Community at-large.

The U.S. Army Medical Command (MEDCOM) is a direct reporting unit of the U.S. Army that formerly provided command and control of the Army's fixed-facility medical, dental, and veterinary treatment facilities, providing preventive care, medical research and development and training institutions. On 1 October 2019, operational and administrative control of all military medical facilities transitioned to the Defense Health Agency.