The brothers of Jesus or the adelphoi are named in the New Testament as James, Joses, Simon, Jude, and unnamed sisters are mentioned in Mark and Matthew. They may have been: (1) the sons of Mary, the mother of Jesus, and Joseph, (2) sons of Mary the wife of Cleophas and sister of Mary, the mother of Jesus; or (3) sons of Joseph by a former marriage. While option 1 is described as the "most natural inference" from the New Testament, those who uphold the perpetual virginity of Mary reject the idea of biological brethren and maintain that the brothers and sisters were either cousins of Jesus or children of Joseph from a previous marriage. The Lutheran Churches have accepted both option 2 and option 3 as being valid explanations for the doctrine of the perpetual virginity of Mary.

Joseph was a 1st-century Jewish man of Nazareth who, according to the canonical Gospels, was married to Mary, the mother of Jesus, and was the legal father of Jesus.