Burlington is an unincorporated community and census-designated place in Lawrence County, Ohio, United States, along the Ohio River. The population was 2,416 at the 2020 census. Connected to neighboring Huntington, West Virginia and connected via the West Huntington Bridge over the Ohio River, it is part of the Huntington–Ashland metropolitan area. Burlington was once the leading community of Lawrence County, being the first county seat and the location of the county's first post office.

Lawrence County is the southernmost county of the U.S. state of Ohio. As of the 2020 census, the population was 58,240. Its county seat is Ironton. The county was created in 1815 and later organized in 1817. It is named for James Lawrence, the naval officer famous for the line "do not give up the ship". Lawrence County is part of the Huntington–Ashland metropolitan area.