The Byzantine Fresco Chapel is a part of the Menil Collection in Houston, Texas, near the University of St. Thomas. From February 1997 to February 2012, it displayed the only intact Byzantine frescoes of this size and importance in the western hemisphere. The Byzantine frescoes had been taken from the church of St. Evphemianos in Lysi, Cyprus in the 1980s. In September 2011, the collection announced that the frescos would be permanently returned to Cyprus in February 2012, following the conclusion of a long-term loan agreement with the Greek Orthodox Church of Cyprus. The frescoes had been presented at the museum by agreement with the Church of Cyprus, their owners, but the church decided not to extend the loan further. They will not return to their original home as Lysi is now in Northern Cyprus, but will be displayed at the Byzantine Museum in Nicosia. On March 4, 2012, the Byzantine Fresco Chapel closed, but re-opened in 2015 for the first in a series of site-specific projects.

The Menil Collection, located in Houston, Texas, refers either to a museum that houses the art collection of founders John de Menil and Dominique de Menil, or to the collection itself of paintings, sculptures, prints, drawings, photographs and rare books.