Côte-Rôtie is a French wine Appellation d'origine contrôlée (AOC) in the northern Rhône wine region of France. The vineyards are located just south of Vienne in the communes of Saint-Cyr-sur-le-Rhône, Ampuis, and Tupin-et-Semons. The vineyards are unique because of the steep slopes facing the river and their stone walls. Côte-Rôtie can be rendered in English as "the roasted slope" and refers to the long hours of sunlight that these steep slopes receive.

The Rhône wine region in Southern France is situated in the Rhône valley and produces numerous wines under various Appellation d'origine contrôlée (AOC) designations. The region's major appellation in production volume is Côtes du Rhône AOC.