The global COVID-19 pandemic arrived in Europe with its first confirmed case in Bordeaux, France, on 24 January 2020, and subsequently spread widely across the continent. By 17 March 2020, every country in Europe had confirmed a case, and all have reported at least one death, with the exception of Vatican City.

The COVID-19 pandemic in Vatican City was a part of the worldwide pandemic of coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2. The Holy See reported the first case of infection in Vatican City on 7 March 2020. Unlike other jurisdictions that report cases within a given territory or cases of residents or citizens of a territory, the Holy See reports on cases "in Vatican City State and among the employees of the Holy See" regardless of location of testing, treatment, or residence. There were 29 confirmed cases of COVID-19 among the Vatican's residents and employees; there were no associated deaths. The 29 cases included 10 employees, 1 new hire, and 1 resident of Vatican City. All those infected tested negative by 6 June 2020. An outbreak among members of the Holy See's Swiss Guard was reported in mid-October, totaling 11 as of October 15.