CSS Tuscaloosa was an ironclad warship that served in the Confederate States Navy during the American Civil War. Construction began in May 1862, under a contract with Henry D. Bassett. Her engines were taken from the steamboat Chewala, and she was armored with 4 inches (10 cm) of iron and armed with four cannons. In January 1863, she was launched, and traveled down to Mobile, Alabama for service on Mobile Bay. Both Tuscaloosa and her sister ship CSS Huntsville were found to be too slow for practical use, and were relegated to service as floating batteries. Union forces captured Mobile in April 1865, and Tuscaloosa was scuttled on April 12, as she was unable to escape due to an inability to steam against the current on the Spanish River. Her wreck was discovered in the 1980s.

Mobile Bay is a shallow inlet of the Gulf of Mexico, lying within the state of Alabama in the United States. Its mouth is formed by the Fort Morgan Peninsula on the eastern side and Dauphin Island, a barrier island on the western side. The Mobile River and Tensaw River empty into the northern end of the bay, making it an estuary. Several smaller rivers also empty into the bay: Dog River, Deer River, and Fowl River on the western side of the bay, and Fish River on the eastern side. Mobile Bay is the fourth-largest estuary in the United States with a discharge of 62,000 cubic feet (1,800 m3) of water per second. Annually, and often several times during the summer months, the fish and crustaceans will swarm the shallow coastline and shore of the bay. This event, appropriately named a jubilee, draws a large crowd because of the abundance of fresh, easily caught seafood.