Cagayan de Oro (CDO), officially the City of Cagayan de Oro, is a 1st class highly urbanized city in the region of Northern Mindanao, Philippines. It is the capital of the province of Misamis Oriental where it is geographically situated but governed administratively independent from the provincial government. According to the 2020 census, it has a population of 728,402 people. Cagayan de Oro also serves as the regional center and business hub of Northern Mindanao, and part of the growing Metropolitan Cagayan de Oro area, which includes the city of El Salvador, the towns of Opol, Alubijid, Laguindingan, Gitagum, Lugait, Naawan, Initao, Libertad and Manticao at the western side, and the towns of Tagoloan, Villanueva, Jasaan, Claveria and Balingasag at the eastern side.

A city is one of the units of local government in the Philippines. All Philippine cities are chartered cities, whose existence as corporate and administrative entities is governed by their own specific municipal charters in addition to the Local Government Code of 1991, which specifies their administrative structure and powers. As of July 8, 2023, there are 149 cities.