Caledonian Airways Flight 153 was a multi-leg nonscheduled passenger service from Luxembourg via Khartoum, Lorenzo Marques, Douala and Lisbon, before heading back to Luxembourg. On 4 March 1962 a Douglas DC-7C flying the route, registration G-ARUD, crashed shortly after takeoff from Douala International Airport, Douala, Cameroon in a swamp on the edge of a jungle 2.4 kilometres off the airport. It is the deadliest crash of a DC-7. It is also the second-deadliest accident in Cameroon surpassed only by Kenya Airways Flight 507.

Douala International Airport is an international airport located in Douala, the largest city in Cameroon and the capital of Cameroon's Littoral Region. With its 4 terminals and an average of 1.5 million passengers and 50,000 tonnes of freight per year, it is the country's busiest airport. The airport is managed and partly owned (34%) by the company Aeroport du Cameroon (ADC) which also manages all other 13 airports on Cameroonian soil.