The Cam Henderson Center is the primary indoor athletics complex at Marshall University in Huntington, West Virginia, USA. The basketball and volleyball teams of the Marshall Thundering Herd use the venue for their home games. The first basketball game played in the facility was a varsity match between Marshall and Army on November 27, 1981. The venue is named for Cam Henderson, who coached football and basketball at the school from 1935 to 1955.

Huntington is a city in Cabell and Wayne counties in the U.S. state of West Virginia. The county seat of Cabell County, the city is located at the confluence of the Ohio and Guyandotte rivers. Huntington is the second-most populous city in West Virginia, with a population of 46,842 as of the 2020 census. Its metro area, the Huntington–Ashland metropolitan area, is the largest in West Virginia, spanning seven counties across three states and having a population of 376,155 at the 2020 census.