The Canada Southern Railway, also known as CSR, was a railway in southwestern Ontario, Canada, founded on February 28, 1868 as the Erie and Niagara Extension Railway. Its name was changed to Canada Southern Railway on December 24, 1869. The 1868 Act specified that it was to be constructed at a broad gauge of 5 ft 6 in, but that requirement was repealed in the 1869 Act, thus allowing construction at the standard gauge of 4 ft 8+1⁄2 in.

The Michigan Central Railroad was originally chartered in 1832 to establish rail service between Detroit, Michigan, and St. Joseph, Michigan. The railroad later operated in the states of Michigan, Indiana, and Illinois in the United States and the province of Ontario in Canada. After about 1867 the railroad was controlled by the New York Central Railroad, which later became part of Penn Central and then Conrail. After the 1998 Conrail breakup, Norfolk Southern Railway now owns much of the former Michigan Central trackage.