Canine distemper virus (CDV) is a viral disease that affects a wide variety of mammal families, including domestic and wild species of dogs, coyotes, foxes, pandas, wolves, ferrets, skunks, raccoons, and felines, as well as pinnipeds, some primates, and a variety of other species. CDV does not affect humans.

The dog is a domesticated descendant of the wolf. Also called the domestic dog, it is derived from extinct gray wolves, and the gray wolf is the dog's closest living relative. The dog was the first species to be domesticated by humans. Experts estimate that hunter-gatherers domesticated dogs more than 15,000 years ago, which was before the development of agriculture. Due to their long association with humans, dogs have expanded to a large number of domestic individuals and gained the ability to thrive on a starch-rich diet that would be inadequate for other canids.