The cantaloupe is a type of true melon from the family Cucurbitaceae. Originally, cantaloupe referred only to the non-netted, orange-fleshed melons of Europe, but today may refer to any orange-fleshed melon of the C. melo species, including the netted muskmelon which is called cantaloupe in North America, rockmelon in Australia and New Zealand, and spanspek in Southern Africa. Cantaloupes range in mass from 0.5 to 5 kilograms.

Cucumis melo, also known as melon, is a species of Cucumis that has been developed into many cultivated varieties. The fruit is a pepo. The flesh is either sweet or bland, with or without a musky aroma, and the rind can be smooth, ribbed, wrinkled, or netted. In North America, the sweet-flesh varieties are often collectively called muskmelon, including the musky netted-rind varieties and the inodorous smooth-rind varieties, and cantaloupe usually refers to the former type. However, muskmelon in a narrow sense only refers to the musky netted-rind type, also known as North American cantaloupe, while the true cantaloupe is the European type with ribbed and often warty rind that is seldom grown in North America.