Canton is a city in Lewis County, Missouri, United States. The population was 2,774 at the 2020 census. Canton is the home of Culver-Stockton College, a small liberal arts college affiliated with the Christian Church. It also had the oldest continuously operating ferry across the Mississippi River, which closed in April 2014. Four members of the United States House of Representatives have come from Canton, and are buried in the city's Forest Grove Cemetery. Canton is part of the Quincy, IL–MO Micropolitan Statistical Area.

Lewis County is a county located in the northeastern portion of the U.S. state of Missouri. As of the 2020 census, the population was 10,032. Its county seat is Monticello. The county was organized January 2, 1833, and named for Meriwether Lewis, the explorer and Governor of the Louisiana Territory.