Carew Tower is a 49-story, 574-foot (175 m) Art Deco building completed in 1931 in the heart of downtown Cincinnati, Ohio, United States, overlooking the Ohio River waterfront. The structure is the second-tallest building in the city, and it was added to the register of National Historic Landmarks on April 19, 1994. The tower is named after Joseph T. Carew, proprietor of the Mabley & Carew department store chain, which had previously operated in a building on the site.

Downtown Cincinnati is one of the 52 neighborhoods of Cincinnati, Ohio. It is the central business district of the city, as well the economic and symbiotic center of the Cincinnati metropolitan area. Originally the densely populated core of the city, the neighborhood was transformed into a commercial zone in the mid-20th century. The population was 5,835 at the 2020 census.