Carlo Gambino was a Sicilian-born American crime boss who was the leader and namesake of the Gambino crime family of New York City. Following the Apalachin Meeting in 1957, and the imprisonment of Vito Genovese in 1959, Gambino took over the Commission of the American Mafia and played a powerful role in organized crime until his death from a heart attack in 1976. During a criminal career that spanned over fifty years, Gambino served only twenty-two months in prison for a tax evasion charge in 1937.

The Gambino crime family is an Italian-American Mafia crime family and one of the "Five Families" that dominate organized crime activities in New York City, within the nationwide criminal phenomenon known as the American Mafia. The group, which went through five bosses between 1910 and 1957, is named after Carlo Gambino, boss of the family at the time of the McClellan hearings in 1963, when the structure of organized crime first gained public attention. The group's operations extend from New York and the eastern seaboard to California. Its illicit activities include labor and construction racketeering, gambling, loansharking, extortion, money laundering, prostitution, fraud, hijacking, and fencing.