Cartagena, known since the colonial era as Cartagena de Indias, is a city and one of the major ports on the northern coast of Colombia in the Caribbean Coast Region, along the Caribbean sea. Cartagena's past role as a link in the route to the West Indies provides it with important historical value for world exploration and preservation of heritage from the great commercial maritime routes. As a former Spanish colony, it was a key port for the export of Bolivian silver to Spain and for the import of enslaved Africans under the asiento system. It was defensible against pirate attacks in the Caribbean. The city's strategic location between the Magdalena and Sinú Rivers also gave it easy access to the interior of New Granada and made it a main port for trade between Spain and its overseas empire, establishing its importance by the early 1540s.

A port is a maritime facility comprising one or more wharves or loading areas, where ships load and discharge cargo and passengers. Although usually situated on a sea coast or estuary, ports can also be found far inland, such as Hamburg, Manchester and Duluth; these access the sea via rivers or canals. Because of their roles as ports of entry for immigrants as well as soldiers in wartime, many port cities have experienced dramatic multi-ethnic and multicultural changes throughout their histories.