Casualties of the Tigray War refers to the civilian and military deaths and injuries in the Tigray War that started in November 2020, in which rape and other sexual violence are also widespread. Precise casualty figures are uncertain. According to researchers at Ghent University in Belgium, as many as 600,000 people had died as a result of war-related violence and famine by late 2022. The scale of the death and destruction led The New York Times to describe it in November 2022 as "one of the world’s bloodiest contemporary conflicts."

The Tigray, officially the Tigray National Regional State, is the northernmost regional state in Ethiopia. The Tigray Region is the homeland of the Tigrayan (Tegaru), Irob people and Kunama people. Its capital and largest city is Mekelle. Tigray is the fifth-largest by area, the fourth-most populous, and the fifth-most densely populated of the 11 regional states.