Caterina Cornaro ossia La Regina di Cipro is a tragedia lirica, or opera, in a prologue and two acts by Gaetano Donizetti. Giacomo Sacchero wrote the Italian libretto after Jules-Henri Vernoy de Saint-Georges' libretto for Halévy's La reine de Chypre (1841). It is based on the life of Caterina Cornaro, Queen of Cyprus from 1474 to 1489. It premiered at the Teatro San Carlo, Naples on 12 January 1844.

Domenico Gaetano Maria Donizetti was an Italian composer, best known for his almost 70 operas. Along with Gioachino Rossini and Vincenzo Bellini, he was a leading composer of the bel canto opera style during the first half of the nineteenth century and a probable influence on other composers such as Giuseppe Verdi. Donizetti was born in Bergamo in Lombardy. At an early age he was taken up by Simon Mayr who enrolled him with a full scholarship in a school which he had set up. There he received detailed musical training. Mayr was instrumental in obtaining a place for Donizetti at the Bologna Academy, where, at the age of 19, he wrote his first one-act opera, the comedy Il Pigmalione, which may never have been performed during his lifetime.