The Cathedral of the Most Blessed Sacrament is a Neo-Gothic style Roman Catholic cathedral church in the United States. It is the seat of the archbishop of the Roman Catholic Archdiocese of Detroit. The metropolitan archdiocese for the Roman Catholic Ecclesiastical Province of Detroit includes all dioceses in the state of Michigan; in addition, in 2000 the archdiocese accepted pastoral responsibility for the Roman Catholic Church in the Cayman Islands, which consists of Saint Ignatius Parish on Grand Cayman. The cathedral is located at 9844 Woodward Avenue in Detroit, Michigan, adjacent to Detroit's Boston-Edison Historic District. The cathedral was listed on the National Register of Historic Places in 1982.

The Boston–Edison Historic District is a neighborhood located in Detroit, Michigan. It consists of over 900 homes built on four east-west streets: West Boston Boulevard, Chicago Boulevard, Longfellow Avenue and Edison Avenue, stretching from Woodward Avenue in the east to Linwood Avenue in the west. It is one of the largest residential historic districts in the nation. It is surrounded by Sacred Heart Major Seminary to the west, the Arden Park-East Boston Historic District and the Cathedral of the Most Blessed Sacrament to the east, and the Atkinson Avenue Historic District to the south. The district was designated a Michigan State Historic Site in 1973 and listed on the National Register of Historic Places in 1975.