Catlettsburg is a former Chesapeake and Ohio Railroad station located in downtown Catlettsburg, Kentucky. Opened between 1897 and 1890 to replace an older wooden station, it served trains until 1958. Amtrak trains began stopping at Tri-State Station some 1.5 miles (2.4 km) to the north in 1975; it was renamed Catlettsburg around 1988. Amtrak service was moved from Catlettsburg to Ashland in 1998. The C&O station was refurbished from 2004 to 2006 and added to the National Register of Historic Places in 2012.

The James Whitcomb Riley was a passenger train that operated between Chicago, Illinois, and Cincinnati, Ohio, via Indianapolis, Indiana. Originally operated by the New York Central Railroad, it was taken over by Amtrak in 1971. Under Amtrak, it merged with the Chesapeake & Ohio Railway's George Washington to become a Chicago-Washington/Newport News train. In 1977, it was renamed the Cardinal, which remains in operation.