The Central Argentine Railway, referred to as CA below, was one of the Big Four broad gauge, 5 ft 6 in British companies that built and operated railway networks in Argentina. The company had been established in the 19th century, to serve the provinces of Santa Fe and Córdoba, in the east-central region of the country. It would later extend its operations to Buenos Aires, Tucumán, and Santiago del Estero. The railroad had a complicated relationship with its employees in the 1910s, and then it had a complicated relationship with the government of Argentina in the 1920s.

Santiago del Estero is the capital of Santiago del Estero Province in northern Argentina. It has a population of 252,192 inhabitants, making it the twelfth largest city in the country, with a surface area of 2,116 km2. It lies on the Dulce River and on National Route 9, at a distance of 1,042 km north-northwest from Buenos Aires. Estimated to be 455 years old, Santiago del Estero was the first city founded by Spanish settlers in the territory that is now Argentina. As such, it is nicknamed "Madre de Ciudades". Similarly, it has been officially declared the "mother of cities and cradle of folklore."