Central High School, also known as High School of Columbus and High School of Commerce, was a four-year secondary school located in Franklinton, Columbus, Ohio. It was a part of Columbus City Schools. On March 7, 1985, the 1924 school building was added to the National Register of Historic Places. It is considered part of the Columbus Civic Center Historic District.

Franklinton is a neighborhood in Columbus, Ohio, just west of its downtown. Settled in 1797, Franklinton is the first American settlement in Franklin County, and was the county seat until 1824. As the city of Columbus grew, the city annexed and incorporated the existing settlement in 1859. Franklinton is bordered by the Scioto River on the north and east, Harmon Avenue on the east, Stimmel Road and Greenlawn Avenue on the south, and Interstate 70 on the west. Its main thoroughfare is West Broad Street, one of the city's two main roads.