Centreville is an incorporated town in Queen Anne's County, Maryland, United States on the Delmarva Peninsula. Incorporated in 1794, it is the county seat of Queen Anne's County. The population was 4,285 at the 2010 census. The ZIP code is 21617 and the area codes are 410 and 443. The primary local telephone exchange is 758. It hosts the Queen Anne's County Fair each summer and was home to three franchises during the existence of the Eastern Shore Baseball League—the Colts, Red Sox, and Orioles.

Queen Anne's County is located on the Eastern Shore of the U.S. state of Maryland. As of the 2020 census, the population was 49,874. Its county seat and most populous municipality is Centreville. The census-designated place of Stevensville is the county's most populous place with population of 7,442 as of 2020. The county is named for Queen Anne of Great Britain, who reigned when the county was established in 1706 during the colonial period.