Centrifugal force is an inertial force in Newtonian mechanics that appears to act on all objects when viewed in a rotating frame of reference. It is directed radially away from the axis of rotation. The magnitude of centrifugal force F on an object of mass m at the distance r from the axis of rotation of a frame of reference rotating with angular velocity ω is:

A centrifuge is a device that uses centrifugal force to subject a specimen to a specified constant force, for example to separate various components of a fluid. This is achieved by spinning the fluid at high speed within a container, thereby separating fluids of different densities or liquids from solids. It works by causing denser substances and particles to move outward in the radial direction. At the same time, objects that are less dense are displaced and moved to the centre. In a laboratory centrifuge that uses sample tubes, the radial acceleration causes denser particles to settle to the bottom of the tube, while low-density substances rise to the top. A centrifuge can be a very effective filter that separates contaminants from the main body of fluid.