Cerignola is a town and comune of Apulia, Italy, in the province of Foggia, 40 kilometres southeast from the town of Foggia. It has the third-largest land area of any comune in Italy, at 593.71 square kilometres (229.23 sq mi), after Rome and Ravenna and it has the largest land area of any comune in Italy among those that are not the provincial capital. In 2017, it had a population of 58,534.

A comune is an administrative division of Italy, roughly equivalent to a township or municipality. It is the third-level administrative division of Italy, after regions and provinces. The comune can also have the title of città.