The Cerro Tololo Inter-American Observatory (CTIO) is an astronomical observatory located on the summit of Mt.Cerro Tololo in the Coquimbo Region of northern Chile, with additional facilities located on Mt. Cerro Pachón about 10 kilometres (6.2 mi) to the southeast. It is approximately 80 kilometres (50 mi) east of La Serena, where support facilities are located. The principal telescopes at CTIO are the 4 m Víctor M. Blanco Telescope, named after Puerto Rican astronomer Víctor Manuel Blanco, and the 4.1 m Southern Astrophysical Research Telescope, which is situated on Cerro Pachón. Other telescopes on Cerro Tololo include the 1.5 m, 1.3 m, 1.0 m, and 0.9 m telescopes operated by the SMARTS consortium. CTIO also hosts other research projects, such as PROMPT, WHAM, and LCOGTN, providing a platform for access to the southern hemisphere for U.S. and worldwide scientific research.

An observatory is a location used for observing terrestrial, marine, or celestial events. Astronomy, climatology/meteorology, geophysics, oceanography and volcanology are examples of disciplines for which observatories have been constructed. Historically, observatories were as simple as containing an astronomical sextant or Stonehenge.