The chancellor of the College of William & Mary is the ceremonial head of the College of William & Mary in Williamsburg, Virginia, United States, chosen by the university's Board of Visitors. The office was created by the college's Royal Charter, which stipulated that the chancellor would serve a seven-year term. Henry Compton, Bishop of London, was named in the Charter as the college's first chancellor. Associate Justice of the Supreme Court of the United States Sandra Day O'Connor served as chancellor from 2005 until 2012 when Robert Gates assumed the office. He was installed as chancellor on February 3, 2012. He was re-invested for a second term on February 8, 2019.

The College of William & Mary in Virginia, is a public research university in Williamsburg, Virginia. Founded in 1693 under a royal charter issued by King William III and Queen Mary II, it is the second-oldest institution of higher education in the United States and the ninth-oldest in the English-speaking world. It is classified among "R2: Doctoral Universities – High Research Activity". In his 1985 book Public Ivies: A Guide to America's Best Public Undergraduate Colleges and Universities, Richard Moll included William & Mary as one of the original eight "Public Ivies". The university is also one of the original nine colonial colleges.