Charles Waterhouse Goodyear was an American lawyer, businessman, lumberman, and member of the prominent Goodyear family of New York. Based in Buffalo, New York, along with his brother, Frank, Charles was the founder and president of several companies, including the Buffalo and Susquehanna Railroad, Great Southern Lumber Company, Goodyear Lumber Company, Buffalo & Susquehanna Coal & Coke Company, and the New Orleans Great Northern Railroad Company.

The Charles W. Goodyear House is located at 888 Delaware Avenue in Buffalo, New York, part of the Delaware Avenue Historic District, a federally designated historic district listed on the National Register of Historic Places since 1974. The Châteauesque house was designed by prominent Buffalo architect Edward Green, of the Buffalo architecture firm Green & Wicks, and was completed in 1903 at a cost of $500,000. The home was built for Charles and Ella Goodyear. Goodyear was a founder and head of several companies including the Buffalo and Susquehanna Railroad, Great Southern Lumber Company, and the New Orleans Great Northern Railroad Company, as well as a director of Marine National Bank, and General Railway Signal.