Charleston is a city in north central Mississippi and one of the two county seats of Tallahatchie County, which is located on both sides of the Tallahatchie River. This city is located east of the river and its population was 2,193 at the 2010 census.

Tallahatchie County is a county in the U.S. state of Mississippi. At the 2020 census, the population was 12,715. Its county seats are Charleston and Sumner.