Cheraw is a town on the Pee Dee River in Chesterfield County, South Carolina, United States. The population was 5,040 at the 2020 census. The greater Cheraw area in the zip code 29520 has a population of 13,689 according to the 2019 ACS data. It has been nicknamed "The Prettiest Town in Dixie".

The Pee Dee River, also known as the Great Pee Dee River, is a river in the Carolinas of the United States. It originates in the Appalachian Mountains in North Carolina, where its upper course, above the mouth of the Uwharrie River, is known as the Yadkin River. The river empties into Winyah Bay, and then into the Atlantic Ocean near Georgetown.