The Cheyenne River, also written Chyone, referring to the Cheyenne people who once lived there, is a tributary of the Missouri River in the U.S. states of Wyoming and South Dakota. It is approximately 295 miles (475 km) long and drains an area of 24,240 square miles (62,800 km2). About 60% of the drainage basin is in South Dakota and almost all of the remainder is in Wyoming.

Badlands National Park is an American national park in southwestern South Dakota. The park protects 242,756 acres of sharply eroded buttes and pinnacles, along with the largest undisturbed mixed grass prairie in the United States. The National Park Service manages the park, with the South Unit being co-managed with the Oglala Lakota tribe.