The Christian Methodist Episcopal (C.M.E.) Church is a historically black denomination that branched from earlier Methodist groups in the Southern United States after the Civil War. It is considered to be a mainline denomination.

The Methodist Episcopal Church, South was the American Methodist denomination resulting from the 19th-century split over the issue of slavery in the Methodist Episcopal Church (MEC). Disagreement on this issue had been increasing in strength for decades between churches of the Northern and Southern United States; in 1845 it resulted in a schism at the General Conference of the MEC held in Louisville, Kentucky.