City Hospital railway station, situated on Donegall Road, serves Belfast City Hospital and the surrounding area of south Belfast, Northern Ireland. It is one of the four stations located in the city centre, the others being Botanic, Lanyon Place, and the under-construction Grand Central.

The Donegall Road is a residential area and road traffic thoroughfare that runs from Shaftesbury Square on what was once called the "Golden Mile" to the Falls Road in west Belfast. The road is bisected by the Westlink – M1 motorway. The largest section of the road, east of the Broadway junction with the Westlink, has a community which self-identifies as predominantly Protestant while the community on the other side of the Westlink – M1 motorway self-identifies as predominantly Catholic.