City of Hope is a private, non-profit clinical research center, hospital and graduate school located in Duarte, California, United States. The center's main campus resides on 110 acres (45 ha) of land adjacent to the boundaries of Duarte and Irwindale, with a network of clinical practice locations throughout Southern California, satellite offices in Monrovia and Irwindale, and regional fundraising offices throughout the United States.

Duarte is a city in Los Angeles County, California, United States. As of the 2020 census, the city population was 21,727. It is bounded to the north by the San Gabriel Mountains, to the north and west by the cities of Bradbury and Monrovia, to the south by the city of Irwindale, and to the east by the cities of Irwindale and Azusa. Duarte is located on historic U.S. Route 66 which today follows Huntington Drive through the middle of the city. The town is named after Andrés Avelino Duarte, a California ranchero who founded the community.